Patrick Dempsey’s wife, Jillian Fink, has filed for divorce after 15 years of marriage.

“It is with careful consideration and mutual respect that we have decided to end our marriage,” the couple said in a statement, People reported. “Our primary concern remains the well-being of our children, and we ask with profound gratitude that you respect our family’s privacy at this very sensitive time.”

Dempsey and Fink have three children together: 12-year-old daughter Tallulah Fyfe and 7-year-old twins Sullivan Patrick and Darby Galen.

Fink, who filed for divorce citing irreconcilable differences, is seeking joint custody of the three children, as well as spousal and child support, TMZ reported.

The couple reportedly does not have a prenup. Dempsey, 49, is estimated to be worth about $40 million.

Dempsey and Fink, a hairstylist and makeup artist, married in 1999. The couple is said to have met several years earlier in Fink’s hair salon. The union was the second marriage for the “Grey’s Anatomy” actor, who had previously been married to actress Rocky Parker.